UCLA college student Jonathan Moore (Anthony Edwards) is playing a game called "Gotcha" (popular on mid-1980s college campuses as "Assassin" or "Tag"), wherein the players are all assigned a mock "hit" on another player by use of a harmless paintball gun. Moore and his apartment roommate Manolo go on a vacation to Paris, France. After touring some of Paris, in a cafe Moore meets Sasha Banicek (Linda Fiorentino), a Czechoslovakian girl. Eventually, Jonathan has intercourse with Sasha, losing his virginity.
Jonathan decides to leave Manolo (who is heading to Spain) and go with Sasha to West Berlin to spend more time with her. Jonathan believes that he is in love with Sasha. There, Jonathan and Sasha continue to have sex and even go to an Oktoberfest beer gathering. One night, Sasha tells Jonathan that she has to go to East Berlin to pick up a package. One night after arriving in East Berlin, Sasha leaves their hotel room and walks to dark street corner. There, Sasha meets a German man who tells her the location of the pickup of her package. Meanwhile, Sasha was being monitored by a Soviet agent, who was sitting in a car at a distance. During the day, Sasha tells Jonathan that if she gives him a certain message, it means that he has to leave East Berlin immediately. At a cafe, Sasha gives Jonathan a package and says that a strudel is inside. A little later, Sasha tells Jonathan to meet her at the butcher shop near their hotel. All of a sudden, a Soviet agent begins to chase after Sasha. Sasha decides to use Jonathan (who is holding her package) to unknowingly get the package over to West Berlin. Meanwhile, Sasha is taken by the Soviet agent and East German secret police.
Jonathan goes to Checkpoint Charlie to cross the heavily fortified border into West Berlin. At the East German customs search, Jonathan is stripped of his clothes and given a cavity search. Meanwhile, Sasha is stripped and searched for possible espionage evidence. Vlad arrives at the border crossing to search for Jonathan, however Jonathan passes the border safely before he can be captured. Once in West Berlin, Jonathan feels liberated by the Westernized society. In the hotel, Jonathan receives a message from Sasha to meet him at a specified location. Jonathan finds out that his hotel room was broken into and robbed of his traveler's checks. Soviet agents eventually find Jonathan in West Berlin and chase him throughout a public park. Jonathan jumps into a water canal and manages to escape from the Soviets and stumbles upon a German rock group headed for Hamburg, who offer him a ride to the airport.
The rock group successfully get Jonathan to the airport (using full-face makeup to sneak him past a checkpoint) and Jonathan finally arrives in Los Angeles Tom Bradley International Airport and to his apartment. Soon, Vlad and a band of Soviet agents arrive too in Los Angeles. Once home, Jonathan stumbles upon a film canister, which was planted by Sasha. Jonathan visits his parents and tells them what happened in Germany but they cannot believe a word of it and think Jonathan is on drugs. Jonathan decides to call the FBI then the Central Intelligence Agency for help. Jonathan returns to find his apartment broken into and looted.
The CIA officer tells Jonathan to give them the photo film canister. At the Los Angeles headquarters of the CIA, Jonathan spots Sasha who looks like she was working there. Jonathan eventually meets up with Sasha. Sasha admits that she is Cheryl Brewster, a CIA agent, originally from Pittsburgh. Out of nowhere, Vlad and his gang begin to chase Jonathan and Cheryl on the UCLA campus. Jonathan eliminates all the Soviets with a tranquilizer gun which he gets from the campus veterinary sciences building. The Soviets are arrested, the CIA agents thank Jonathan for his (indirect) help in obtaining the film, and Sasha tells him she wants to continue their relationship.
After they part, Jonathan talks to a pretty student who rebuffs him coldly. As she walks away, he aims the tranquilizer pistol and shoots her in the rear.
月球，袋鼠，孤独的环月之旅，点亮地球的信号。这一切都很浪漫啊！宇宙永远浪漫！最关键还有作品的完整性和工业电影质感。能在这破烂日子里，银幕上看到这样的国产电影，感慨更多一层。
一想到中国人进电影院看这种东西，就打心底觉得可怜又可惜
开心麻花还是老老实实专注喜剧类型吧，突然想起之前某个电影的热评，《流浪地球》代表中国迈出科幻的一大步，又被《独行月球》给倒退回去了……
预计这个暑期档最好看的喜剧！不仅含腾量超标，惊喜的是看到了沈腾作为一个演员的优秀，大量的独角戏和无实物表演，在希望和绝望中的情绪转换，甚至让我感觉有点向卓别林致敬的意味。推荐。
这踏马7分？这踏马7分？沈腾演得远超期待，笑点、泪点、视听感受都很棒，导演太能调动观众情绪了！难道是憋得太狠？反正我觉得这是近两年院线看过的最好的电影，几乎完美！
只能说，剧情到最后，可以确定引进不了了，编剧不了解十二生肖，强行套用中国元素，有被恶心到。
开心麻花在创作上的核心方法论还是没有变，因此堆叠实打实工业化的东西也只是看起来愈发尴尬。幕布拉开发现没有真正的情感，甚至也没有真正的谎言，所有人习惯了之后大可以熟视无睹，于是中国电影继续在虚无且稀薄的空气上建筑摩天高楼。
无聊的笑点，傻逼的剧情，平均五分钟低头看一次时间。。要不是朋友想看我早他妈的提前离场了。^_^
这个张吃鱼真的很烂，把沈腾钉在耻辱柱上了，揭下了开心麻花最后一块遮羞布。
优点是非常认真地在服务老百姓做娱乐产品，有突破，腾哥真的牛，不愧齐齐哈尔三杰之首。视效出色，郝瀚老师的刚子演得真不错，狠狠代入了。有浪漫到，鼠拉雪橇致敬外星人帅的。内在短板是喜剧和科幻两个类型打架，一般来说融合需要以其中一个为主，这个片在拼命端水，俩都很使劲儿效果会抵消一部分，我觉得再减少一些无用笑点给独孤月一些安静下来的时间让我们真的体验到他的孤独，肯定会更好。但麻花基因也没办法，很多观众就是要看二人转看小品。塞得满，会导致故事容量太大，节奏太赶，一半叙事用华彩剪辑真的让人吃不消，也根本没工夫深入人物。不要自行车的话，总的来说是挺可看的。
月球版夸父追日+太空版董存瑞炸碉堡
恭喜主旋律电影，再添一员大将。
好可爱 但是麻烦真的不要再搞什么功夫了 能不能新潮点 别老整些俗腔滥调点
好久没在电影院看过这么让人如芒刺背，如坐针毡，如鲠在喉的电影了
马蓝星，独孤月的“异球恋”也太浪漫了吧～独孤月最后还是写完了那封信啊，最后那个信封的特写看得人泪目
在三星和四星之间犹豫，还是四星吧，多一星给沈腾和马丽的表演。同样的处境，马丽的表演比倪妮在《拆弹2》里的好太多了。独孤月闯入马蓝星房间并擦番茄汁那段略低俗，麻花可以试着高级一点的。另外，我觉得称赞英雄确实是有必要的，不能矫枉过正。不能因为理解明哲保身的无奈，就不称赞英雄舍己为人的伟大。
总的来说像是演的幼儿动画片，更适合小朋友，对于成年人是降智片。
算是这两年开心麻花最佳，沈腾叔叔孤独又浪漫的喜剧表演值得一个影帝！！
只能说，剧情到最后，可以确定引进不了了，编剧不了解十二生肖，强行套用中国元素，有被恶心到。
无可救药的浪漫，让我无视他任何的逻辑问题无可救药的要给满分
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